About stem cell clinic
Small-molecule inhibitors with the serine dipeptidases DPP8 and DPP9 (DPP8/nine) induce a lytic sort of cell death termed pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/nine inhibition activates the inflammasome sensor Nlrp1b, which consequently activates Professional-caspase-1 to mediate cell death3, thoug